Cytosim  PI
Cytoskeleton Simulator
Parameters of ClassicFiber

Variables

real growing_speed [2]
 see ClassicFiber More...
 
real growing_force
 Characteristic force of assembly state. More...
 
real shrinking_speed
 speed of disassembly state
 
real catastrophe_rate [2]
 Rate of stochastic switch from assembly to disassembly. More...
 
real rescue_rate
 Rate of stochastic switch from disassembly to assembly.
 
real min_length
 Minimum authorized length. More...
 
Fate fate
 Action that is taken when the fiber shrinks below min_length
 

Detailed Description

Inherits Parameters of Fiber.

Variable Documentation

real catastrophe_rate[2]

The catastrophe rate depends on the growth rate of the corresponding tip, which is itself reduced by antagonistic force.
The correspondance is :

1/catastrophe_rate = a + b * growth_speed

where growth_speed is calculated as explained in growing_speed, and parameters a and b are derived from:

  • catastrophe_rate[0] = the catastrophe rate in the absence of force.
  • catastrophe_rate[1] = the catastrophe rate of a stalled tip.
real growing_force

Antagonistic force decrease assembly rate exponentially.

real growing_speed[2]

Speed of assembly state

growth_speed = monomer_fraction * growing_speed[0] * exp(force/growing_force) + growing_speed[1];

monomer_fraction in [0,1] reflect the amount of free monomers. Antagonistic force is negative ( force < 0 ). Force directed in the same direction as assembly has no effect.

The parameters are:

  • growing_speed[0] = force-dependent assembly rate.
  • growing_speed[1] = constant term, which can be negative to represent spontaneous disassembly.
  • growing_force = characteristic force
real min_length

When the fiber becomes shorter than min_length, the action specified by fate is applied.